Research on glandular secretions and their metabolic impact transfigured the medico-scientific understanding of the body in the late 19th century. In 1905, British physiologist Ernest H. Starling (1866–1927) coined the word “hormone,” an umbrella term for secretions from various parts of the body. In the subsequent decades, glandular science flourished and fueled a refashioning of concepts such as aging, growth, reproduction, and sex/gender. This panel sheds light on various ways in which the hormonal view of the body impacted 20th-century science in Asia, Europe, and North America. What role did glands and hormones fulfill in scientific and social lives at different times and places? What hopes and fears were associated with interfering in the hormonal body? To what extent were hormone-related practices and theories mobile across space and time? The papers exemplify multiple connotations of hormones: they could be both promises and threats to human health, as well as disruptors or justifications of the contemporary social order. Furthermore, due to the double role of hormones as actively sexing/gendering (through their metabolic function) and passively sexed/gendered substances (through social ascriptions), hormonal theories and practices transcended the binaries between nature and nurture, and between the physical and the social world.